Ontology highlight
ABSTRACT:
SUBMITTER: Batram C
PROVIDER: S-EPMC4027811 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Batram Christopher C Jones Nicola G NG Janzen Christian J CJ Markert Sebastian M SM Engstler Markus M
eLife 20140520
We have discovered a new mechanism of monoallelic gene expression that links antigenic variation, cell cycle, and development in the model parasite Trypanosoma brucei. African trypanosomes possess hundreds of variant surface glycoprotein (VSG) genes, but only one is expressed from a telomeric expression site (ES) at any given time. We found that the expression of a second VSG alone is sufficient to silence the active VSG gene and directionally attenuate the ES by disruptor of telomeric silencing ...[more]