Positive selection of primate genes that promote HIV-1 replication.
Ontology highlight
ABSTRACT:
SUBMITTER: Meyerson NR
PROVIDER: S-EPMC4028154 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Publications
Positive selection of primate genes that promote HIV-1 replication.
Meyerson Nicholas R NR Rowley Paul A PA Swan Christina H CH Le Dona T DT Wilkerson Gregory K GK Sawyer Sara L SL
Virology 20140321
Evolutionary analyses have revealed that most host-encoded restriction factors against HIV have experienced virus-driven selection during primate evolution. However, HIV also depends on the function of many human proteins, called host factors, for its replication. It is not clear whether virus-driven selection shapes the evolution of host factor genes to the extent that it is known to shape restriction factor genes. We show that five out of 40 HIV host factor genes (13%) analyzed do bear strong ...[more]
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