Ontology highlight
ABSTRACT:
SUBMITTER: Magarkar A
PROVIDER: S-EPMC4028897 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Scientific reports 20140521
Cholesterol is an important component of all biological membranes as well as drug delivery liposomes. We show here that increasing the level of cholesterol in a phospholipid membrane decreases surface charge in the physiological environment. Through molecular dynamics simulation we have shown that increasing the level of cholesterol decreases Na+ ion binding. Complementary experimental ζ--potential measurements have shown a decreased ζ--potential with increasing cholesterol content, indicative o ...[more]