Ontology highlight
ABSTRACT:
SUBMITTER: Nieznanski K
PROVIDER: S-EPMC4030797 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Nieznanski Krzysztof K Surewicz Krystyna K Chen Shugui S Nieznanska Hanna H Surewicz Witold K WK
ACS chemical neuroscience 20140401 5
Recent studies indicate that the pathogenesis of Alzheimer disease may be related to the interaction between prion protein (PrP) and certain oligomeric species of Aβ peptide. However, the mechanism of this interaction remains unclear and controversial. Here we provide direct experimental evidence that, in addition to previously demonstrated binding to Aβ oligomers, PrP also interacts with mature Aβ fibrils. However, contrary to the recent claim that PrP causes fragmentation of Aβ fibrils into ol ...[more]