The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity.
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ABSTRACT:
SUBMITTER: Wilkinson SM
PROVIDER: S-EPMC4030799 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
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The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity.
Wilkinson Shane M SM Gunosewoyo Hendra H Barron Melissa L ML Boucher Aurelie A McDonnell Michelle M Turner Peter P Morrison Daniel E DE Bennett Maxwell R MR McGregor Iain S IS Rendina Louis M LM Kassiou Michael M
ACS chemical neuroscience 20140403 5
Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7 receptor (P2X7R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to modify CNS activity. ...[more]
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