Ontology highlight
ABSTRACT:
SUBMITTER: Speijer D
PROVIDER: S-EPMC4032520 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Speijer D D Manjeri G R GR Szklarczyk R R
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20140701 1646
Oxygen radical formation in mitochondria is an incompletely understood attribute of eukaryotic cells. Recently, a kinetic model was proposed, in which the ratio between electrons entering the respiratory chain via FADH2 or NADH determines radical formation. During glucose breakdown, the ratio is low; during fatty acid breakdown, the ratio is high (the ratio increasing--asymptotically--with fatty acid length to 0.5, when compared with 0.2 for glucose). Thus, fatty acid oxidation would generate hi ...[more]