Altered global brain signal in schizophrenia.
Ontology highlight
ABSTRACT:
SUBMITTER: Yang GJ
PROVIDER: S-EPMC4034208 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Publications
Altered global brain signal in schizophrenia.
Yang Genevieve J GJ Murray John D JD Repovs Grega G Cole Michael W MW Savic Aleksandar A Glasser Matthew F MF Pittenger Christopher C Krystal John H JH Wang Xiao-Jing XJ Pearlson Godfrey D GD Glahn David C DC Anticevic Alan A
Proceedings of the National Academy of Sciences of the United States of America 20140505 20
Neuropsychiatric conditions like schizophrenia display a complex neurobiology, which has long been associated with distributed brain dysfunction. However, no investigation has tested whether schizophrenia shows alterations in global brain signal (GS), a signal derived from functional MRI and often discarded as a meaningless baseline in many studies. To evaluate GS alterations associated with schizophrenia, we studied two large chronic patient samples (n = 90, n = 71), comparing them to healthy s ...[more]
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