Ontology highlight
ABSTRACT:
SUBMITTER: Hosur V
PROVIDER: S-EPMC4040562 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Hosur Vishnu V Johnson Kenneth R KR Burzenski Lisa M LM Stearns Timothy M TM Maser Richard S RS Shultz Leonard D LD
Proceedings of the National Academy of Sciences of the United States of America 20140513 21
The rhomboid 5 homolog 2 (Rhbdf2) gene encodes an inactive rhomboid (iRhom) protease, iRhom2, one of a family of enzymes containing a long cytosolic N terminus and a dormant peptidase domain of unknown function. iRhom2 has been implicated in epithelial regeneration and cancer growth through constitutive activation of epidermal growth factor receptor (EGFR) signaling. However, little is known about the physiological substrates for iRhom2 or the molecular mechanisms underlying these functions. We ...[more]