Rapid air infusion into the oesophagus: Motor response in patients with achalasia and nonobstructive dysphagia assessed with high-resolution manometry.

ABSTRACT: BACKGROUND: Achalasia is a neurodegenerative disorder of the oesophagus. Alteration of motor activity induced by oesophageal distension has not been explored. OBJECTIVES: To investigate this function, using high-resolution Manometry. METHODS: This study enrolled 15 healthy subjects, 15 nonobstructive dysphagia (NOD), and 18 achalasia patients successfully treated with pneumatic dilation (six with restored peristalsis). The three groups underwent five rapid (<1?s) intraoesophageal infusions of 20-ml air boluses, followed by eight 5-ml water swallows. RESULTS: WHEREAS THE RESPONSE RATE TO WATER SWALLOWS WAS SIMILAR IN THE THREE GROUPS, AIR INFUSION INDUCED A LOWER RESPONSE RATE IN ACHALASIA (MEDIAN, INTERQUARTILE RANGE: 70%, 40-100%) and, to a lesser extent, in NOD patients (100%, 60-100%) than in healthy subjects (100%, 100-100%; p?

SUBMITTER: Elvevi A 

PROVIDER: S-EPMC4040817 | biostudies-other | 2014 Apr

REPOSITORIES: biostudies-other