Human neoplasms elicit multiple specific immune responses in the autologous host.
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ABSTRACT:
SUBMITTER: Sahin U
PROVIDER: S-EPMC40492 | biostudies-other | 1995 Dec
REPOSITORIES: biostudies-other
Publications
Human neoplasms elicit multiple specific immune responses in the autologous host.
Sahin U U Türeci O O Schmitt H H Cochlovius B B Johannes T T Schmits R R Stenner F F Luo G G Schobert I I Pfreundschuh M M
Proceedings of the National Academy of Sciences of the United States of America 19951201 25
Expression of cDNA libraries from human melanoma, renal cancer, astrocytoma, and Hodgkin disease in Escherichia coli and screening for clones reactive with high-titer IgG antibodies in autologous patient serum lead to the discovery of at least four antigens with a restricted expression pattern in each tumor. Besides antigens known to elicit T-cell responses, such as MAGE-1 and tyrosinase, numerous additional antigens that were overexpressed or specifically expressed in tumors of the same type we ...[more]
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