Ontology highlight
ABSTRACT:
SUBMITTER: Chirila AM
PROVIDER: S-EPMC4050559 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Chirila Anda M AM Brown Travis E TE Bishop Rachel A RA Bellono Nicholas W NW Pucci Francesco G FG Kauer Julie A JA
Proceedings of the National Academy of Sciences of the United States of America 20140515 22
Long-term potentiation (LTP) is a persistent increase in synaptic strength required for many behavioral adaptations, including learning and memory, visual and somatosensory system functional development, and drug addiction. Recent work has suggested a role for LTP-like phenomena in the processing of nociceptive information in the dorsal horn and in the generation of central sensitization during chronic pain states. Whereas LTP of glutamatergic and GABAergic synapses has been characterized throug ...[more]