High-density 3D single molecular analysis based on compressed sensing.
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ABSTRACT:
SUBMITTER: Gu L
PROVIDER: S-EPMC4052265 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Publications
High-density 3D single molecular analysis based on compressed sensing.
Gu Lusheng L Sheng Yi Y Chen Yan Y Chang Hao H Zhang Yongdeng Y Lv Pingping P Ji Wei W Xu Tao T
Biophysical journal 20140601 11
Single molecule fitting-based superresolution microscopy achieves sub-diffraction-limit image resolution but suffers from a need for long acquisition times to gather enough molecules. Several methods have recently been developed that analyze high molecule density images but most are only applicable to two dimensions. In this study, we implemented a high-density superresolution localization algorithm based on compressed sensing and a biplane approach that provides three-dimensional information ab ...[more]
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