A computational model for the loss of neuronal organization in microcolumns.
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ABSTRACT:
SUBMITTER: Henderson M
PROVIDER: S-EPMC4052343 | biostudies-other | 2014 May
REPOSITORIES: biostudies-other
Publications
A computational model for the loss of neuronal organization in microcolumns.
Henderson Maxwell M Urbanc Brigita B Cruz Luis L
Biophysical journal 20140501 10
A population of neurons in the cerebral cortex of humans and other mammals organize themselves into vertical microcolumns perpendicular to the pial surface. Anatomical changes to these microcolumns have been correlated with neurological diseases and normal aging; in particular, in area 46 of the rhesus monkey brain, the strength of microcolumns was shown to decrease with age. These changes can be caused by alterations in the spatial distribution of the neurons in microcolumns and/or neuronal los ...[more]
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