Ontology highlight
ABSTRACT:
SUBMITTER: Dekaminaviciute D
PROVIDER: S-EPMC4055155 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Dekaminaviciute Dovile D Lasickiene Rita R Parkkila Seppo S Jogaite Vaida V Matuliene Jurgita J Matulis Daumantas D Zvirbliene Aurelija A
BioMed research international 20140520
Carbonic anhydrases (CAs) are enzymes that catalyse the reversible hydration of CO2 to bicarbonate. CA XII is considered a potential biomarker of tumor cells and a promising target for specific therapies. The aim of the current study was to develop new monoclonal antibodies (MAbs) against human recombinant CA XII and evaluate their diagnostic potential. An extracellular catalytic domain of human CA XII was expressed in E. coli and used as an immunogen. Seven stable hybridoma cell lines producing ...[more]