Ontology highlight
ABSTRACT:
SUBMITTER: Walker MC
PROVIDER: S-EPMC4057101 | biostudies-other | 2013 Sep
REPOSITORIES: biostudies-other
Walker Mark C MC Thuronyi B W BW Charkoudian Louise K LK Lowry Brian B Khosla Chaitan C Chang Michelle C Y MC
Science (New York, N.Y.) 20130901 6150
Organofluorines represent a rapidly expanding proportion of molecules that are used in pharmaceuticals, diagnostics, agrochemicals, and materials. Despite the prevalence of fluorine in synthetic compounds, the known biological scope is limited to a single pathway that produces fluoroacetate. Here, we demonstrate that this pathway can be exploited as a source of fluorinated building blocks for introduction of fluorine into natural-product scaffolds. Specifically, we have constructed pathways invo ...[more]