Ontology highlight
ABSTRACT:
SUBMITTER: Tamzalit F
PROVIDER: S-EPMC4060713 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Tamzalit Fella F Barbieux Isabelle I Plet Ariane A Heim Julie J Nedellec Steven S Morisseau Sébastien S Jacques Yannick Y Mortier Erwan E
Proceedings of the National Academy of Sciences of the United States of America 20140527 23
Interleukin (IL)-15 and its specific receptor chain, IL-15Rα, support the development of various effector cells, including NK and CD8 T cells via a mechanism called trans-presentation. Whereas the dynamic of trans-presentation has been shown to involve the recycling of IL-15Rα by presenting cells, the way responding cells integrate, or take advantage of this process has not been evaluated yet. To address this question, we set up a trans-presentation model using a membrane-bound IL-15.IL-15Rα fus ...[more]