Ontology highlight
ABSTRACT:
SUBMITTER: Smith IJ
PROVIDER: S-EPMC4062832 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Smith Ira J IJ Godinez Guillermo L GL Singh Baljit K BK McCaughey Kelly M KM Alcantara Raniel R RR Gururaja Tarikere T Ho Melissa S MS Nguyen Henry N HN Friera Annabelle M AM White Kathy A KA McLaughlin John R JR Hansen Derek D Romero Jason M JM Baltgalvis Kristen A KA Claypool Mark D MD Li Wei W Lang Wayne W Yam George C GC Gelman Marina S MS Ding Rongxian R Yung Stephanie L SL Creger Daniel P DP Chen Yan Y Singh Rajinder R Smuder Ashley J AJ Wiggs Michael P MP Kwon Oh-Sung OS Sollanek Kurt J KJ Powers Scott K SK Masuda Esteban S ES Taylor Vanessa C VC Payan Donald G DG Kinoshita Taisei T Kinsella Todd M TM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20140326 7
Controlled mechanical ventilation (CMV) is associated with the development of diaphragm atrophy and contractile dysfunction, and respiratory muscle weakness is thought to contribute significantly to delayed weaning of patients. Therefore, therapeutic strategies for preventing these processes may have clinical benefit. The aim of the current study was to investigate the role of the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in CMV-mediated diap ...[more]