Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1.
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SUBMITTER: Moore A
PROVIDER: S-EPMC4073808 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
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Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1.
Moore Andrew A Shindikar Amol A Fomison-Nurse Ingrid I Riu Federica F Munasinghe Pujika E PE Ram Thrishila Parshu TP Saxena Pankaj P Coffey Sean S Bunton Richard W RW Galvin Ivor F IF Williams Michael J A MJ Emanueli Costanza C Madeddu Paolo P Katare Rajesh R
Cardiovascular diabetology 20140401
<h4>Background</h4>Diabetic women are five times more likely to develop congestive heart failure compared with two fold for men. The underlying mechanism for this gender difference is not known. Here we investigate the molecular mechanisms responsible for this female disadvantage and attempt safeguarding cardiomyocytes viability and function through restoration of pro-survival Pim-1.<h4>Methods and results</h4>Diabetes was induced by injection of streptozotocin in CD1 mice of both genders. Funct ...[more]
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