Ontology highlight
ABSTRACT:
SUBMITTER: Bishop JL
PROVIDER: S-EPMC4074806 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Bishop Jennifer L JL Thaper Daksh D Zoubeidi Amina A
Cancers 20140409 2
The signal transducer and activator of transcription (STAT)3 governs essential functions of epithelial and hematopoietic cells that are often dysregulated in cancer. While the role for STAT3 in promoting the progression of many solid and hematopoietic malignancies is well established, this review will focus on the importance of STAT3 in prostate cancer progression to the incurable metastatic castration-resistant prostate cancer (mCRPC). Indeed, STAT3 integrates different signaling pathways invol ...[more]