Coagulopathy following major trauma hemorrhage: lytic, lethal and a lack of fibrinogen.
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ABSTRACT:
SUBMITTER: Davenport R
PROVIDER: S-EPMC4075417 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
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Coagulopathy following major trauma hemorrhage: lytic, lethal and a lack of fibrinogen.
Critical care (London, England) 20140616 3
Trauma-induced coagulopathy (TIC) is present soon after injury and is associated with increased transfusion requirements and worse outcomes. The pathophysiological mechanisms, which result in the widespread derangements of hemostasis following major trauma hemorrhage, are as yet not fully defined. Profound activation of fibrinolytic pathways and fibrinogen depletion appear to be fundamental processes in the development of TIC and offer potential therapeutic targets. Collaborative and multi-disci ...[more]
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