Ontology highlight
ABSTRACT:
SUBMITTER: Grove KJ
PROVIDER: S-EPMC4076088 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Grove Kerri J KJ Voziyan Paul A PA Spraggins Jeffrey M JM Wang Suwan S Paueksakon Paisit P Harris Raymond C RC Hudson Billy G BG Caprioli Richard M RM
Journal of lipid research 20140526 7
Diabetic nephropathy (DN) is a major life-threatening complication of diabetes. Renal lesions affect glomeruli and tubules, but the pathogenesis is not completely understood. Phospholipids and glycolipids are molecules that carry out multiple cell functions in health and disease, and their role in DN pathogenesis is unknown. We employed high spatial resolution MALDI imaging MS to determine lipid changes in kidneys of eNOS(-/-) db/db mice, a robust model of DN. Phospholipid and glycolipid structu ...[more]