Ontology highlight
ABSTRACT:
SUBMITTER: Gabus C
PROVIDER: S-EPMC407820 | biostudies-other | 2004
REPOSITORIES: biostudies-other
Gabus Caroline C Mazroui Rachid R Tremblay Sandra S Khandjian Edouard W EW Darlix Jean-Luc JL
Nucleic acids research 20040419 7
The fragile X syndrome is the most common cause of inherited mental retardation resulting from the absence of the fragile X mental retardation protein (FMRP). FMRP contains two K-homology (KH) domains and one RGG box that are landmarks characteristic of RNA-binding proteins. In agreement with this, FMRP associates with messenger ribonucleoparticles (mRNPs) within actively translating ribosomes, and is thought to regulate translation of target mRNAs, including its own transcript. To investigate w ...[more]