Ontology highlight
ABSTRACT:
SUBMITTER: Ermann J
PROVIDER: S-EPMC4078823 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Ermann Joerg J Staton Tracy T Glickman Jonathan N JN de Waal Malefyt Rene R Glimcher Laurie H LH
Proceedings of the National Academy of Sciences of the United States of America 20140609 25
T-bet(-/-).Rag2(-/-) (TRUC) mice spontaneously develop microbiota-driven, TNF-mediated large bowel inflammation that resembles human ulcerative colitis. We show here that IL-23 and IL-1-dependent secretion of IL-17A by innate lymphoid cells (ILCs; defined as CD45(+)lin(-)Thy1(hi)NKp46(-)) is a second critical pathway in this model. Using an in vitro coculture system of bone marrow-derived dendritic cells (DCs) and freshly isolated FACS-purified ILCs, we demonstrate that IL-23 and IL-1 secreted b ...[more]