Ontology highlight
ABSTRACT:
SUBMITTER: Biswas AK
PROVIDER: S-EPMC4083823 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Biswas Anup Kumar AK Mitchell David L DL Johnson David G DG
Cancer research 20140416 12
In response to DNA damage, the E2F1 transcription factor is phosphorylated at serine 31 (serine 29 in mouse) by the ATM or ATR kinases, which promotes E2F1 protein stabilization. Phosphorylation of E2F1 also leads to the recruitment of E2F1 to sites of DNA damage, where it functions to enhance DNA repair. To study the role of this E2F1 phosphorylation event in vivo, a knock-in mouse model was generated, in which serine 29 was mutated to alanine. The S29A mutation impairs E2F1 stabilization in re ...[more]