Outcome markers for clinical trials in cerebral amyloid angiopathy.
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ABSTRACT:
SUBMITTER: Greenberg SM
PROVIDER: S-EPMC4085787 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
Publications
Outcome markers for clinical trials in cerebral amyloid angiopathy.
Greenberg Steven M SM Al-Shahi Salman Rustam R Biessels Geert Jan GJ van Buchem Mark M Cordonnier Charlotte C Lee Jin-Moo JM Montaner Joan J Schneider Julie A JA Smith Eric E EE Vernooij Meike M Werring David J DJ
The Lancet. Neurology 20140227 4
Efforts are underway for early-phase trials of candidate treatments for cerebral amyloid angiopathy, an untreatable cause of haemorrhagic stroke and vascular cognitive impairment. A major barrier to these trials is the absence of consensus on measurement of treatment effectiveness. A range of potential outcome markers for cerebral amyloid angiopathy can be measured against the ideal criteria of being clinically meaningful, closely representative of biological progression, efficient for small or ...[more]
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