Ontology highlight
ABSTRACT:
SUBMITTER: Bellefontaine N
PROVIDER: S-EPMC4089460 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Bellefontaine Nicole N Chachlaki Konstantina K Parkash Jyoti J Vanacker Charlotte C Colledge William W d'Anglemont de Tassigny Xavier X Garthwaite John J Bouret Sebastien G SG Prevot Vincent V
The Journal of clinical investigation 20140508 6
The transition to puberty and adult fertility both require a minimum level of energy availability. The adipocyte-derived hormone leptin signals the long-term status of peripheral energy stores and serves as a key metabolic messenger to the neuroendocrine reproductive axis. Humans and mice lacking leptin or its receptor fail to complete puberty and are infertile. Restoration of leptin levels in these individuals promotes sexual maturation, which requires the pulsatile, coordinated delivery of gon ...[more]