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Sleep duration and age-related changes in brain structure and cognitive performance.


ABSTRACT: STUDY OBJECTIVES: To investigate the contribution of sleep duration and quality to age-related changes in brain structure and cognitive performance in relatively healthy older adults. DESIGN: Community-based longitudinal brain and cognitive aging study using a convenience sample. SETTING: Participants were studied in a research laboratory. PARTICIPANTS: Relatively healthy adults aged 55 y and older at study commencement. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Participants underwent magnetic resonance imaging and neuropsychological assessment every 2 y. Subjective assessments of sleep duration and quality and blood samples were obtained. Each hour of reduced sleep duration at baseline augmented the annual expansion rate of the ventricles by 0.59% (P = 0.007) and the annual decline rate in global cognitive performance by 0.67% (P = 0.050) in the subsequent 2 y after controlling for the effects of age, sex, education, and body mass index. In contrast, global sleep quality at baseline did not modulate either brain or cognitive aging. High-sensitivity C-reactive protein, a marker of systemic inflammation, showed no correlation with baseline sleep duration, brain structure, or cognitive performance. CONCLUSIONS: In healthy older adults, short sleep duration is associated with greater age-related brain atrophy and cognitive decline. These associations are not associated with elevated inflammatory responses among short sleepers. CITATION: Lo JC, Loh KK, Zheng H, Sim SK, Chee MW. Sleep duration and age-related changes in brain structure and cognitive performance.

SUBMITTER: Lo JC 

PROVIDER: S-EPMC4098802 | biostudies-other | 2014 Jul

REPOSITORIES: biostudies-other

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Sleep duration and age-related changes in brain structure and cognitive performance.

Lo June C JC   Loh Kep Kee KK   Zheng Hui H   Sim Sam K Y SK   Chee Michael W L MW  

Sleep 20140701 7


<h4>Study objectives</h4>To investigate the contribution of sleep duration and quality to age-related changes in brain structure and cognitive performance in relatively healthy older adults.<h4>Design</h4>Community-based longitudinal brain and cognitive aging study using a convenience sample.<h4>Setting</h4>Participants were studied in a research laboratory.<h4>Participants</h4>Relatively healthy adults aged 55 y and older at study commencement.<h4>Interventions</h4>N/A.<h4>Measurements and resu  ...[more]

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