Ontology highlight
ABSTRACT:
SUBMITTER: Rinkevich Y
PROVIDER: S-EPMC4103362 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Rinkevich Yuval Y Montoro Daniel T DT Muhonen Ethan E Walmsley Graham G GG Lo David D Hasegawa Masakazu M Januszyk Michael M Connolly Andrew J AJ Weissman Irving L IL Longaker Michael T MT
Proceedings of the National Academy of Sciences of the United States of America 20140623 27
The requirement and influence of the peripheral nervous system on tissue replacement in mammalian appendages remain largely undefined. To explore this question, we have performed genetic lineage tracing and clonal analysis of individual cells of mouse hind limb tissues devoid of nerve supply during regeneration of the digit tip, normal maintenance, and cutaneous wound healing. We show that cellular turnover, replacement, and cellular differentiation from presumed tissue stem/progenitor cells wit ...[more]