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Horizons in therapy for corneal angiogenesis.

ABSTRACT: Corneal neovascularization can lead to a devastating disease process that involves the breakdown of the limbal barrier and the formation of blood vessels in the cornea, leading to severe visual impairment. This review discusses the delicate balance between antiangiogenic and angiogenic factors that govern the antiangiogenic privilege of the cornea. Current treatment methods, clinical trials, and future prospects in the management of corneal neovascularization also are discussed.

SUBMITTER: Maddula S

PROVIDER: S-EPMC4107641 | biostudies-other | 2011 Mar

REPOSITORIES: biostudies-other

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Horizons in therapy for corneal angiogenesis.

Maddula Surekha S Davis Don K DK Maddula Soumya S Burrow Michael K MK Ambati Balamurali K BK

Ophthalmology 20110301 3

Corneal neovascularization can lead to a devastating disease process that involves the breakdown of the limbal barrier and the formation of blood vessels in the cornea, leading to severe visual impairment. This review discusses the delicate balance between antiangiogenic and angiogenic factors that govern the antiangiogenic privilege of the cornea. Current treatment methods, clinical trials, and future prospects in the management of corneal neovascularization also are discussed. ...[more]

PMID: 21376242

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