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Complete sequence of the bithorax complex of Drosophila.

ABSTRACT: The bithorax complex (BX-C) of Drosophila, one of two complexes that act as master regulators of the body plan of the fly, is included within a sequence of 338,234 bp (SEQ89E). This paper presents the strategy used in sequencing SEQ89E and an analysis of its open reading frames. The BX-C sequence (BXCALL) contains 314,895 bp obtained by deletion of putative genes that are located at each end of SEQ89E and appear to be functionally unrelated to the BX-C. Only 1.4% of BXCALL codes for the three homeodomain-containing proteins of the complex. Principal findings include a putative ABD-A protein (ABD-AII) larger than a previously known ABD-A protein and a putative glucose transporter-like gene (1521 bp) located at or near the bithoraxoid (bxd), infra-abdominal-2 (iab-2) boundary on the opposite strand relative to that of the homeobox-containing genes.

SUBMITTER: Martin CH

PROVIDER: S-EPMC41164 | biostudies-other | 1995 Aug

REPOSITORIES: biostudies-other

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Complete sequence of the bithorax complex of Drosophila.

Martin C H CH Mayeda C A CA Davis C A CA Ericsson C L CL Knafels J D JD Mathog D R DR Celniker S E SE Lewis E B EB Palazzolo M J MJ

Proceedings of the National Academy of Sciences of the United States of America 19950801 18

The bithorax complex (BX-C) of Drosophila, one of two complexes that act as master regulators of the body plan of the fly, is included within a sequence of 338,234 bp (SEQ89E). This paper presents the strategy used in sequencing SEQ89E and an analysis of its open reading frames. The BX-C sequence (BXCALL) contains 314,895 bp obtained by deletion of putative genes that are located at each end of SEQ89E and appear to be functionally unrelated to the BX-C. Only 1.4% of BXCALL codes for the three ho ...[more]

PMID: 7667301

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Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila.

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