Dataset Information

Characteristics and survival of patients with advanced cancer and p53 mutations.

ABSTRACT: P53 mutations are associated with invasive tumors in mouse models. We assessed the p53mutations and survival in patients with advanced cancer treated in the Phase I Program. Of 691 tested patients, 273 (39.5%) had p53 mutations. Patients with p53 mutations were older (p<.0001) and had higher numbers of liver metastases (p=.005). P53 mutations were associated with higher numbers of other aberrations; PTEN (p=.0005) and HER2 (p=.003)aberrations were more common in the p53 mutation group. No survival difference was observed between patients with p53 mutations and those with wild-type p53. In patients with wild-type p53 and other aberrations, patients treated with matched-therapy against the additional aberrations had longer survival compared to those treated with non-matched-therapy or those who received no therapy (median survival, 26.0 vs. 11.8 vs. 9.8 months, respectively; p= .0007). Results were confirmed in a multivariate analysis (p= .0002). In the p53 mutation group with additional aberrations, those who received matched-therapy against the additional aberrations had survival similar to those treated with non-matched-therapy or those who received no therapy (p=.15). In conclusion, our results demonstrated resistance to matched-targeted therapy to the other aberrations in patients with p53 mutations and emphasize the need to overcome this resistance.

SUBMITTER: Said R

PROVIDER: S-EPMC4116527 | biostudies-other | 2014 Jun

REPOSITORIES: biostudies-other

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Characteristics and survival of patients with advanced cancer and p53 mutations.

Said Rabih R Ye Yang Y Hong David S DS Janku Filip F Fu Siqing S Naing Aung A Wheler Jennifer J JJ Kurzrock Razelle R Thomas Christoforos C Palmer Gary A GA Hess Kenneth R KR Aldape Kenneth K Tsimberidou Apostolia M AM

Oncotarget 20140601 11

P53 mutations are associated with invasive tumors in mouse models. We assessed the p53mutations and survival in patients with advanced cancer treated in the Phase I Program. Of 691 tested patients, 273 (39.5%) had p53 mutations. Patients with p53 mutations were older (p<.0001) and had higher numbers of liver metastases (p=.005). P53 mutations were associated with higher numbers of other aberrations; PTEN (p=.0005) and HER2 (p=.003)aberrations were more common in the p53 mutation group. No surviv ...[more]

PMID: 25003695

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Dataset Information

Characteristics and survival of patients with advanced cancer and p53 mutations.

Publications

Characteristics and survival of patients with advanced cancer and p53 mutations.

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