Conformation, energy, and folding ability of selected amino acid sequences.
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ABSTRACT:
SUBMITTER: Sasai M
PROVIDER: S-EPMC41172 | biostudies-other | 1995 Aug
REPOSITORIES: biostudies-other
Publications
Conformation, energy, and folding ability of selected amino acid sequences.
Proceedings of the National Academy of Sciences of the United States of America 19950801 18
Evolutionary selection of sequences is studied with a knowledge-based Hamiltonian to find the design principle for folding to a model protein structure. With sequences selected by naive energy minimization, the model structure tends to be unstable and the folding ability is low. Sequences with high folding ability have only the low-lying energy minimum but also an energy landscape which is similar to that found for the native sequence over a wide region of the conformation space. Though there is ...[more]
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