Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC4124205 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Chen Chen C Fan Huahao H Huang Yong Y Peng Fan F Fan Hang H Yuan Shoujun S Tong Yigang Y
BioMed research international 20140716
The advent of methicillin-resistant Staphylococcus aureus (MRSA) and the frequent and excessive abuse of ventilators have made MRSA pneumonia an inordinate threat to human health. Appropriate antibacterial therapies are crucial, including the use of lysostaphin as an alternative to antibiotics. To explore the potential use of lysostaphin as a therapeutic agent for MRSA pneumonia, mice were intranasally infected with MRSA and then treated with recombinant lysostaphin (rLys; 45 mg/kg in the high-d ...[more]