Ontology highlight
ABSTRACT:
SUBMITTER: Saka SK
PROVIDER: S-EPMC4124874 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Saka Sinem K SK Honigmann Alf A Eggeling Christian C Hell Stefan W SW Lang Thorsten T Rizzoli Silvio O SO
Nature communications 20140725
Most proteins have uneven distributions in the plasma membrane. Broadly speaking, this may be caused by mechanisms specific to each protein, or may be a consequence of a general pattern that affects the distribution of all membrane proteins. The latter hypothesis has been difficult to test in the past. Here, we introduce several approaches based on click chemistry, through which we study the distribution of membrane proteins in living cells, as well as in membrane sheets. We found that the plasm ...[more]