Ontology highlight
ABSTRACT:
SUBMITTER: Wierenga CE
PROVIDER: S-EPMC4124882 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Wierenga Christina E CE Clark Lindsay R LR Dev Sheena I SI Shin David D DD Jurick Sarah M SM Rissman Robert A RA Liu Thomas T TT Bondi Mark W MW
Journal of Alzheimer's disease : JAD 20130101 4
We investigated the impact of APOE genotype on cerebral blood flow (CBF) in older and younger adults. Forty cognitively normal older adults (16 ε4 carriers, 24 non-ε4 carriers) and 30 younger adults (15 ε4 carriers, 15 non-ε4 carriers) completed a resting-state whole-brain pulsed arterial spin labeling magnetic resonance scan. Main effects of aging were demonstrated wherein older adults had decreased gray matter CBF corrected for partial volume effects compared to younger adults in widespread br ...[more]