Dataset Information

Associations between TNF-?-308A/G polymorphism and susceptibility with dermatomyositis: a meta-analysis.

ABSTRACT: BACKGROUND: Some surveys had inspected the effects of the tumor necrosis factor-? (TNF-?)-308A/G polymorphism on susceptibility to dermatomyositis (DM), and showed mixed results. To briefly review these consequences, a comprehensive meta-analysis was carried out to estimate the relationship between them much more accurately. METHODS: Relevant documents dated to February 2014 were acquired from the PUBMED, MEDLINE, and EMBASE databases. The number of the genotypes and/or alleles for the TNF-?-308A/G in the DM and control subjects was extracted and statistical analysis was conducted using STATA 11.2 software. Summary odds ratios (ORs) with their 95% confidence intervals (95% CIs) were used to calculate the risk of DM with TNF-?-308A/G. Stratified analysis based on ethnicity and control population source was also performed. RESULTS: 555 patients with DM and 1005 controls from eight published investigations were finally involved in this meta-analysis. Combined analysis revealed that the overall ORs for the TNF-?-308A allele were 2.041 (95% CIs 1.528-2.725, P<0.0001) in DM. Stratification by ethnicity indicated the TNF-?-308A allele polymorphism was found to be significantly associated with DM in Europeans (OR?=?1.977, 95% CI 1.413-2.765, P<0.0001). The only study conducted on TNF-?-308A/G polymorphism in Asians could not be used in ethnicity-stratified meta-analysis. Meta-analysis of the AA+AG vs. GG (dominant model) and AA vs. GG (additive model) of this polymorphism revealed a significant association with DM in overall populations and Europeans. CONCLUSIONS: Our meta-analysis demonstrated that the TNF-?-308A/G polymorphism in the TNF gene might contribute to DM susceptibility, especially in European population. However, further studies with large sample sizes and among different ethnicity populations should be required to verify the association.

SUBMITTER: Chen S

PROVIDER: S-EPMC4125139 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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Associations between TNF-α-308A/G polymorphism and susceptibility with dermatomyositis: a meta-analysis.

Chen Si S Wang Qian Q Wu Ziyan Z Wu Qingjun Q Li Ping P Li Yuan Y Li Jing J Deng Chuiwen C Wu Chanyuan C Gao Lei L Zhang Fengchun F Li Yongzhe Y

PloS one 20140807 8

<h4>Background</h4>Some surveys had inspected the effects of the tumor necrosis factor-α (TNF-α)-308A/G polymorphism on susceptibility to dermatomyositis (DM), and showed mixed results. To briefly review these consequences, a comprehensive meta-analysis was carried out to estimate the relationship between them much more accurately.<h4>Methods</h4>Relevant documents dated to February 2014 were acquired from the PUBMED, MEDLINE, and EMBASE databases. The number of the genotypes and/or alleles for ...[more]

PMID: 25101759

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Project description:Background and objectiveThe association between TNF-α -308 G/A polymorphism and COPD remains controversial due to insufficiently strict study designs and small group sizes among different studies. In the present study, a meta-analysis update which followed a stricter procedure was performed to obtain a clearer understanding of this association.MethodsA comprehensive database search was conducted to identify the case-control studies published up to July 2015 which reported an association between the TNF-α -308 G/A polymorphism and COPD risk. Data were extracted to calculate pooled odds ratios with 95% confidence intervals under the most appropriate genetic and allelic models. Sensitivity was analyzed, and heterogeneity as well as publication bias was assessed.ResultsThirty-eight eligible studies, comprising 3,951 COPD cases and 5,110 controls, were included in this study, among which 22 studies comprising 2,067 COPD cases and 2,167 controls were performed in Asians, and 16 studies comprising 1,884 COPD cases and 2,943 controls were in non-Asians. The overall result showed that TNF-α -308 G/A polymorphisms were significantly associated with increased COPD risk in both the codominant genetic and allelic models. Individuals with the GA or AA genotype were more susceptible to COPD development than those with the GG genotype. In addition, individuals with the AA genotype were more susceptible to developing COPD than those with the GA genotype. The subgroup analysis stratified by ethnicity supported the results in Asians but not in non-Asians. However, no association was found between TNF-α -308 G/A polymorphisms and COPD susceptibility either in Asians or in non-Asians in the meta-analysis conducted with restriction to former/current smokers.ConclusionThe present meta-analysis suggested that the TNF-α -308 G/A polymorphism was associated with an increased risk of COPD among Asians but not in non-Asians. Furthermore, individuals with the AA genotype of TNF-α -308 were more susceptible to developing COPD.

Project description:Background and aim:Despite several studies being conducted to examine the associations between the NUDT15 R139C polymorphism and thiopurine-induced leukopenia in the Asian population, the results remain inconsistent. This meta-analysis determined the risk of thiopurine-induced leukopenia conferred by the NUDT15 R139C polymorphism. Materials and methods:All eligible studies published in English up to May 2018 were identified by searching PubMed, Web of Science, Embase, and the Cochrane Library. Pooled OR and 95% CI were calculated using fixed- or random-effect model. Results:In all, total of 14 studies containing 918 patients and 2,341 controls were included; of these, 8 studies concerned inflammatory bowel disease (IBD) and 4 concerned acute lymphoblastic leukemia (ALL). Overall, the results indicated that the NUDT15 R139C polymorphism was associated with leukopenia induced by thiopurines (OR =9.04, 95% CI 6.05-13.50, P<0.001 for the dominant model; OR =24.26, 95% CI 11.38-51.71, P<0.001 for the recessive model; OR =7.60, 95% CI 4.97-11.61, P<0.001 for the CT vs TT model; OR =38.47, 95% CI 17.78-83.24, P<0.001 for the CC vs TT model). In subgroup analyses, significant associations were found among patients with IBD (OR =7.57, 95% CI 5.16-11.12, P<0.001 for the dominant model), ALL (OR =13.13, 95% CI 3.43-50.23 P<0.001 for the dominant model), and other diseases (OR =31.22, 95% CI 1.20-814.07, P=0.04 for the dominant model). In addition, the R139C variant was strongly associated with early (<8 weeks) (OR =15.53, 95% CI 7.91-30.50, P<0.001 for the dominant model) and late leukopenia (?8 weeks) (OR =2.92, 95% CI 2.01-4.24, P<0.001 for the dominant model). Moreover, these findings were sufficiently robust when studies without Hardy-Weinberg equilibrium test were excluded. Conclusion:This meta-analysis verified the strong association between the NUDT15 R139C polymorphism and thiopurine-induced leukopenia (both early and late leukopenia) in an Asian population with IBD, ALL, and other diseases. NUDT15 R139C genotyping should be prioritized to predict leukopenia among Asians.

Dataset Information

Associations between TNF-?-308A/G polymorphism and susceptibility with dermatomyositis: a meta-analysis.

Publications

Associations between TNF-α-308A/G polymorphism and susceptibility with dermatomyositis: a meta-analysis.

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