Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer.
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ABSTRACT:
SUBMITTER: Valente G
PROVIDER: S-EPMC4127242 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Publications
Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer.
Valente Guido G Morani Federica F Nicotra Giuseppina G Fusco Nicola N Peracchio Claudia C Titone Rossella R Alabiso Oscar O Arisio Riccardo R Katsaros Dyonissios D Benedetto Chiara C Isidoro Ciro C
BioMed research international 20140717
Autophagy is dysregulated in cancer and might be involved in ovarian carcinogenesis. BECLIN-1, a protein that interacts with either BCL-2 or PI3k class III, plays a critical role in the regulation of both autophagy and cell death. Induction of autophagy is associated with the presence of vacuoles characteristically labelled with the protein LC3. We have studied the biological and clinical significance of BECLIN 1 and LC3 in ovary tumours of different histological types. The positive expression o ...[more]
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