Ontology highlight
ABSTRACT:
SUBMITTER: Lebron MB
PROVIDER: S-EPMC4128863 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Lebron Maria B MB Brennan Laura L Damoci Christopher B CB Prewett Marie C MC O'Mahony Marguerita M Duignan Inga J IJ Credille Kelly M KM DeLigio James T JT Starodubtseva Marina M Amatulli Michael M Zhang Yiwei Y Schwartz Kaben D KD Burtrum Douglas D Balderes Paul P Persaud Kris K Surguladze David D Loizos Nick N Paz Keren K Kotanides Helen H
Cancer biology & therapy 20140612 9
Stem cell factor receptor (c-Kit) exerts multiple biological effects on target cells upon binding its ligand stem cell factor (SCF). Aberrant activation of c-Kit results in dysregulated signaling and is implicated in the pathogenesis of numerous cancers. The development of more specific and effective c-Kit therapies is warranted given its essential role in tumorigenesis. In this study, we describe the biological properties of CK6, a fully human IgG1 monoclonal antibody against the extracellular ...[more]