Ontology highlight
ABSTRACT:
SUBMITTER: Taglieri DM
PROVIDER: S-EPMC4129940 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Cellular signalling 20140502 9
P-21 activated kinases, or PAKs, are serine-threonine kinases that serve a role in diverse biological functions and organ system diseases. Although PAK signaling has been the focus of many investigations, still our understanding of the role of PAK in inflammation is incomplete. This review consolidates what is known about PAK1 across several cell types, highlighting the role of PAK1 and PAK2 in inflammation in relation to NADPH oxidase activation. This review explores the physiological functions ...[more]