Bridge between neuroimmunity and traumatic brain injury.
Ontology highlight
ABSTRACT:
SUBMITTER: Kelso ML
PROVIDER: S-EPMC4135046 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Publications
Bridge between neuroimmunity and traumatic brain injury.
Kelso Matthew L ML Gendelman Howard E HE
Current pharmaceutical design 20140101 26
The pathophysiology of degenerative, infectious, inflammatory and traumatic diseases of the central nervous system includes a significant immune component. As to the latter, damage to the cerebral vasculature and neural cell bodies, caused by traumatic brain injury (TBI) activates innate immunity with concomitant infiltration of immunocytes into the damaged nervous system. This leads to proinflammatory cytokine and prostaglandin production and lost synaptic integrity and more generalized neuroto ...[more]
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