Comparison of different drug susceptibility test methods to detect rifampin heteroresistance in Mycobacterium tuberculosis.
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ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC4135805 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Publications
Comparison of different drug susceptibility test methods to detect rifampin heteroresistance in Mycobacterium tuberculosis.
Zhang Zhijian Z Wang Yufeng Y Pang Yu Y Liu Changting C
Antimicrobial agents and chemotherapy 20140714 9
We compared the efficiencies of different drug susceptibility testing methods in detecting rifampin (RIF) heteroresistance in Mycobacterium tuberculosis. Our data revealed that the broth dilution method found more resistance than MGIT did (P=0.046) for the low-resistance group. Similarly, the broth dilution method was more sensitive in detecting RIF heteroresistance in subpopulations with low growth rates than was MGIT (P=0.033). In conclusion, our data demonstrated that the broth dilution metho ...[more]
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