Unknown

Dataset Information

0

Colistin heteroresistance in Enterobacter cloacae is associated with cross-resistance to the host antimicrobial lysozyme.


ABSTRACT: Here, we describe the first identification of colistin-heteroresistant Enterobacter cloacae in the United States. Treatment of this isolate with colistin increased the frequency of the resistant subpopulation and induced cross-resistance to the host antimicrobial lysozyme. This is the first description of heteroresistance conferring cross-resistance to a host antimicrobial and suggests that clinical treatment with colistin may inadvertently select for bacteria that are resistant to components of the host innate immune system.

SUBMITTER: Napier BA 

PROVIDER: S-EPMC4135841 | biostudies-other | 2014 Sep

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC7699182 | biostudies-literature
| S-EPMC8268410 | biostudies-literature
| PRJEB22680 | ENA
| S-EPMC4862446 | biostudies-literature
| S-EPMC4658791 | biostudies-literature
| S-EPMC3147620 | biostudies-literature
| S-EPMC5964641 | biostudies-literature
| S-EPMC9832134 | biostudies-literature
| S-EPMC10129329 | biostudies-literature
| S-EPMC5383897 | biostudies-literature