Ontology highlight
ABSTRACT:
SUBMITTER: Napier BA
PROVIDER: S-EPMC4135841 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Napier Brooke A BA Band Victor V Burd Eileen M EM Weiss David S DS
Antimicrobial agents and chemotherapy 20140630 9
Here, we describe the first identification of colistin-heteroresistant Enterobacter cloacae in the United States. Treatment of this isolate with colistin increased the frequency of the resistant subpopulation and induced cross-resistance to the host antimicrobial lysozyme. This is the first description of heteroresistance conferring cross-resistance to a host antimicrobial and suggests that clinical treatment with colistin may inadvertently select for bacteria that are resistant to components of ...[more]