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Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa.

ABSTRACT: Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon.

SUBMITTER: Frangipani E 

PROVIDER: S-EPMC4135843 | biostudies-other | 2014 Sep

REPOSITORIES: biostudies-other

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Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa.

Frangipani Emanuela E   Bonchi Carlo C   Minandri Fabrizia F   Imperi Francesco F   Visca Paolo P  

Antimicrobial agents and chemotherapy 20140623 9

Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon. ...[more]