Ontology highlight
ABSTRACT:
SUBMITTER: Kubori T
PROVIDER: S-EPMC4136560 | biostudies-other | 2014 Aug
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20140725 32
Bacterial type IV secretion systems are evolutionarily related to conjugation systems and play a pivotal role in infection by delivering numerous virulence factors into host cells. Using transmission electron microscopy, we report the native molecular structure of the core complex of the Dot/Icm type IV secretion system encoded by Legionella pneumophila, an intracellular human pathogen. The biochemically isolated core complex, composed of at least five proteins--DotC, DotD, DotF, DotG, and DotH- ...[more]