Ontology highlight
ABSTRACT:
SUBMITTER: Ise W
PROVIDER: S-EPMC4136626 | biostudies-other | 2014 Aug
REPOSITORIES: biostudies-other
Ise Wataru W Inoue Takeshi T McLachlan James B JB Kometani Kohei K Kubo Masato M Okada Takaharu T Kurosaki Tomohiro T
Proceedings of the National Academy of Sciences of the United States of America 20140728 32
In primary humoral responses, B-cell lymphoma 6 (Bcl6) is a master regulator of follicular helper T (TFH) cell differentiation; however, its activation mechanisms and role in memory responses remain unclear. Here we demonstrate that survival of CXCR5(+) TFH memory cells, and thus subsequent recall antibody response, require Bcl6 expression. Furthermore, we show that, upon rechallenge with soluble antigen Bcl6 in memory TFH cells is rapidly induced in a dendritic cell-independent manner and that ...[more]