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Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells.


ABSTRACT: In primary humoral responses, B-cell lymphoma 6 (Bcl6) is a master regulator of follicular helper T (TFH) cell differentiation; however, its activation mechanisms and role in memory responses remain unclear. Here we demonstrate that survival of CXCR5(+) TFH memory cells, and thus subsequent recall antibody response, require Bcl6 expression. Furthermore, we show that, upon rechallenge with soluble antigen Bcl6 in memory TFH cells is rapidly induced in a dendritic cell-independent manner and that peptide:class II complexes (pMHC) on cognate memory B cells significantly contribute to this induction. Given the previous evidence that antigen-specific B cells residing in the follicles acquire antigens within minutes of injection, our results suggest that memory B cells present antigens to the cognate TFH memory cells, thereby contributing to rapid Bcl6 reexpression and differentiation of the TFH memory cells during humoral memory responses.

SUBMITTER: Ise W 

PROVIDER: S-EPMC4136626 | biostudies-other | 2014 Aug

REPOSITORIES: biostudies-other

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Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells.

Ise Wataru W   Inoue Takeshi T   McLachlan James B JB   Kometani Kohei K   Kubo Masato M   Okada Takaharu T   Kurosaki Tomohiro T  

Proceedings of the National Academy of Sciences of the United States of America 20140728 32


In primary humoral responses, B-cell lymphoma 6 (Bcl6) is a master regulator of follicular helper T (TFH) cell differentiation; however, its activation mechanisms and role in memory responses remain unclear. Here we demonstrate that survival of CXCR5(+) TFH memory cells, and thus subsequent recall antibody response, require Bcl6 expression. Furthermore, we show that, upon rechallenge with soluble antigen Bcl6 in memory TFH cells is rapidly induced in a dendritic cell-independent manner and that  ...[more]

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