Ontology highlight
ABSTRACT:
SUBMITTER: Hutcheson R
PROVIDER: S-EPMC4139908 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Hutcheson Rebecca R Chaplin Jennifer J Hutcheson Brenda B Borthwick Faye F Proctor Spencer S Gebb Sarah S Jadhav Rashmi R Smith Erika E Russell James C JC Rocic Petra P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20140605 9
Inadequate cell proliferation is considered a major causative factor for impaired coronary collateral growth (CCG). Proangiogenic growth factors (GFs) stimulate cell proliferation, but their administration does not promote CCG in patients. These GFs are increased in patients with metabolic syndrome and in animal models, where CCG is impaired. Here, we investigated whether excessive cell proliferation underlies impaired CCG in metabolic syndrome. Normal [Sprague-Dawley (SD)] and metabolic syndrom ...[more]