Ontology highlight
ABSTRACT:
SUBMITTER: Kushwaha D
PROVIDER: S-EPMC4147303 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Kushwaha Deepa D Ramakrishnan Valya V Ng Kimberly K Steed Tyler T Nguyen Thien T Futalan Diahnn D Akers Johnny C JC Sarkaria Jann J Jiang Tao T Chowdhury Dipanjan D Carter Bob S BS Chen Clark C CC
Oncotarget 20140601 12
MGMT expression is a critical determinant for therapeutic resistance to DNA alkylating agents. We previously demonstrated that MGMT expression is post-transcriptionally regulated by miR-181d and other miRNAs. Here, we performed a genome-wide screen to identify MGMT regulating miRNAs. Candidate miRNAs were further tested for inverse correlation with MGMT expression in clinical specimens. We identified 15 candidate miRNAs and characterized the top candidate, miR-603. Transfection of miR-603 suppre ...[more]