Ontology highlight
ABSTRACT:
SUBMITTER: Mahony D
PROVIDER: S-EPMC41540 | biostudies-other | 1995 Jul
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19950701 14
We have cloned a type I serine/threonine kinase receptor, XTrR-I, from Xenopus. XTrR-I (Xenopus transforming growth factor beta-related receptor type I) is expressed in all regions of embryos throughout early development. Overexpression of this receptor does not affect ectoderm or endoderm but dorsalizes the mesoderm such that muscle appears in ventral mesoderm and notochord appears in lateral mesoderm normally fated to become muscle. In addition, overexpression of XTrR-I in UV-treated embryos i ...[more]