Ontology highlight
ABSTRACT:
SUBMITTER: Smolen KK
PROVIDER: S-EPMC4157060 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Smolen Kinga K KK Cai Bing B Fortuno Edgardo S ES Fortuno Edgardo S ES Gelinas Laura L Larsen Martin M Speert David P DP Chamekh Mustapha M Cooper Philip J PJ Esser Monika M Marchant Arnaud A Kollmann Tobias R TR
Journal of immunology (Baltimore, Md. : 1950) 20140818 6
Innate immunity instructs adaptive immunity, and suppression of innate immunity is associated with an increased risk for infection. We showed previously that whole-blood cellular components from a cohort of South African children secreted significantly lower levels of most cytokines following stimulation of pattern recognition receptors compared with whole blood from cohorts of Ecuadorian, Belgian, or Canadian children. To begin dissecting the responsible molecular mechanisms, we set out to iden ...[more]