Ontology highlight
ABSTRACT:
SUBMITTER: Agarwala V
PROVIDER: S-EPMC4158716 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Agarwala Vineeta V Flannick Jason J Sunyaev Shamil S Altshuler David D
Nature genetics 20131020 12
The genetic architecture of human diseases governs the success of genetic mapping and the future of personalized medicine. Although numerous studies have queried the genetic basis of common disease, contradictory hypotheses have been advocated about features of genetic architecture (for example, the contribution of rare versus common variants). We developed an integrated simulation framework, calibrated to empirical data, to enable the systematic evaluation of such hypotheses. For type 2 diabete ...[more]